Indiana State @ Duke Blue Devils NCAA Basketball 11/14/2025

Friday night college hoops with a betting edge—that’s the vibe as Indiana State rolls into Durham to face Duke in Matchday 2 of the NCAA D1 regular season. Recent form leans Blue Devils (4-1 over their last five), and Indiana State has held its own (3-2), but home-court and talent depth paint a clear picture. From a wagering standpoint, this one sets up across all three core markets—moneyline, spread, and total—with the Sycamores’ pace-and-space profile nudging the Over into the conversation, while Duke’s two-way efficiency makes them the rightful favorite. Below, we’ll break down our best angles and why they align with how these teams have been trending. We’ll keep it tight, data-informed, and actionable, with probabilities and fair odds in American format to guide your decision-making.

Before you make your pick between the Blue Devils and Sycamores, compare the NCAA Basketball betting odds across top sportsbooks — small shifts in the line can make a big difference on your bet slip

Our betting predictions for the match Indiana State Sycamores @ Duke Blue Devils

Main Tip: Moneyline – Duke to Win

Moneyline: Duke to win (fair odds at BetMGM Sportsbook). Duke’s recent form, talent depth, and the early-season defensive buy-in give them multiple win conditions. Indiana State has shown fight, but this is a step up in class on the road. If the market posts anything shorter, it’s a viable piece for parlays or a straight-confidence stake. Betting tip: Duke moneyline (consider as a parlay anchor or straight if you’re comfortable with the juice).

Tip 2: Spread – Duke -18.5

Expert Prediction 2 — Spread: Duke against the spread (up to -18.5), typical pricing around -110 with bet365. The Blue Devils have been winning with separation, and their wings are shooting it with confidence. If Duke controls the glass and limits transition threes, the middle stretches of each half should swing this toward a cover. Shop the number—anything at -18.5 or better keeps this in play. Betting tip: Duke -18.5 or better, with an eye on late movement.

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Tip 3: Game Totals – Over 149.5 Points

Expert Prediction 3 — Total: Over 149.5 (typical pricing around -110 with bet365). Indiana State’s recent profile trends toward higher possessions and efficient perimeter looks. Duke’s offense hums at home, and second-chance scoring plus free throws are catalysts for totals. If tempo holds and both teams shoot near their season norms, this clears the number more often than not. Tip: Over 149.5 at -110 with bet365.

Team Statistics

• Duke Blue Devils (last five): 4 wins, 1 loss. Offensively, they’ve been efficient early—spacing, drive-and-kick rhythm, and steady free-throw output. Their defense has produced stretches of lockdown basketball, particularly when they control the glass and set their half-court shell.
• Indiana State Sycamores (recent trend indicators): – Last five: 3 wins, 2 losses – Scoring average: about 84.8 points per game
• Opponent scoring average: about 76.6 points per game – Against the spread: near 50% in the recent sample
• Totals: leaning over in a majority of recent outings. These Sycamores can run and shoot, and they’ve posted numbers suggesting comfort in higher totals. That tempo interplay with Duke’s offensive talent is a key driver behind the Over recommendation.

Keyplayer Statistics/Momentum/External Factors

• Duke wings have delivered high-efficiency shooting in recent outings, including strong percentages from deep and at the line. The perimeter group has flashed upside with multiple players capable of stringing together scoring bursts.
• Depth note: Duke’s rotation has looked cohesive despite early-season noise about health and availability across college hoops. The next-man-up approach has been encouraging for bettors seeking consistency in favorite roles.
• Indiana State’s guard/wing collective is the engine. Recent showings suggest they’re comfortable generating pace and finding shooters in rhythm. One recent highlight performance featured an explosive scoring guard leading the way—encouraging for those considering the Over.
• External factors: Home-court energy typically elevates Duke’s intensity on both ends. For Indiana State, composure in the first eight minutes will matter; if turnovers spike early, it can quickly tilt the spread.

Last direct match Duke Blue Devils vs Indiana State Sycamores

No recent head-to-head information is available at this level, so we’re working from current form, program profiles, and early-season trends rather than historical results between these two.

Performance last 5 matches

• Duke Blue Devils: 4 wins, 1 loss
• Indiana State Sycamores: 3 wins, 2 losses.

The Blue Devils have had more dominant stretches within games, while Indiana State’s profile shows spurts of offense that can snowball when the shots fall.

Last match results Duke Blue Devils and Indiana State Sycamores

• Duke: Won on the road by a 55-point margin in their most recent outing—a statement of intent on both ends of the floor and a strong indicator of their ceiling when the offense and defense sync.
• Indiana State: Won on the road by 9 points in their latest game, a steady performance that showcased resilience in late-game possessions.

Duke Blue Devils: Current Form and Betting Read

Duke’s form line is convincing. After a 4-1 stretch, the Blue Devils are playing to their strengths—shooting with confidence, getting to the line, and putting together extended defensive stands. Even when the outside shot cools, offensive rebounding and interior touches have given them cover. That’s the foundation behind our heavier moneyline probability and the willingness to lay points on the spread up to a threshold. Betting takeaway: they’re demonstrating the profile of a team that not only wins but can win with a margin, especially at home.

From a total angle, Duke’s offense contributes to elevated game scores when opponents are capable of pushing the pace. If Indiana State commits to early-clock looks, Duke’s transition game (and the free-throw parade that can come with it) helps the Over. Add in the Blue Devils’ recent perimeter accuracy, and the offensive potential is clear.

Indiana State Sycamores: Current Form and Betting Read

Indiana State’s last five show a winning record, and the scoring average points to an offense that doesn’t mind turning games into track meets. They’ve leaned toward Overs, which aligns with a push-and-fire philosophy and a willingness to let shooters work into volume. That creates a narrow path to an upset, but more realistically, it builds a case for the total. Defensively, they’ve allowed opponents to find comfortable looks in stretches; against a team like Duke, that can be problematic if the Blue Devils get downhill and force closeouts.

In a spread context, Indiana State’s best counter is shot variance—hit enough threes to keep this within mid-teens. But Duke’s length and closing speed tend to erode that edge over 40 minutes. That’s why our spread lean sits with Duke, even while we acknowledge the Sycamores’ offensive spunk that supports the Over.

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TrustnBet Final Thoughts

We’re backing the fundamentals here: – Duke moneyline is our confidence play. It’s chalky, but the risk-reward works as a single or parlay anchor given Duke’s two-way ceiling and home-court comfort. – Duke against the spread up to -18.5 (58% cover probability at about -110) captures what we’ve seen from the Blue Devils: ability to stack runs, create separation, and hold it with defense and the free-throw line. – Over 149.5 (55% probability at about -110) aligns with Indiana State’s pace-driven profile and Duke’s offensive efficiency. If the Sycamores hit enough threes and Duke gets to the stripe, this total trends north.

How we got here: Duke’s recent dominance, Indiana State’s scoring pace, and the home/road dynamic set the stage for a favorite with cover potential and a total that leans Over. As always, monitor the number—value is a function of price. If the spread inflates past -20 or the total surges into the mid-150s, recalibrate your stake sizes. But at the current projections, these three angles make sense, fit the form, and have the percentages to back them.