Los Angeles Rams @ San Francisco 49ers 11/09/2025
Two NFC West rivals meet in Santa Clara on Sunday, November 9 (4:25 ET), and it’s got that classic West Coast juice: Sean McVay’s Rams rolling in at 6-2 against Kyle Shanahan’s 49ers at 6-3. Quick snapshot for the betting crowd: the Rams have profiled as one of the league’s most balanced outfits through eight games, averaging about 26.1 points per game while holding opponents to roughly 15.9. The Niners aren’t far behind on offense, sitting at about 21.6 points per game across nine, and their defense is giving up about 20.9.
Levi’s Stadium has been kind to San Francisco (2-1 at home), while the Rams have handled the road (3-1 away), putting up a steady 27.8 points per road game and allowing just 15.5. That travel form matters here. The last meeting between these teams? An overtime grinder that ended 26-23 for San Francisco after it was 10-7 at the end of regulation—proof these sides know how to turn a division game into a long haul. Momentum tilts slightly toward L.A. with four wins in the last five, while the Niners are 3-2 in their last five.
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Our betting predictions for the match Los Angeles Rams @ San Francisco 49ers
Main Tip: Game Totals – Over 49.5 Points
First tip — Game Totals Over/Under 49.5 points (Our betting prediction): Lean Over 49.5 at -115 at ESPN BET. The Rams’ offense has traveled well, averaging 27.8 on the road, and their defense creates short fields with timely stops. San Francisco, at home, is averaging about 19.0 points with a defense around 17.0 allowed, but this matchup has a way of opening up late, especially when both coaches script well and adjust out of halftime. With playmakers on both sides and special teams capable of flipping field position, a 27-24 type shootout is live. Tip: Over 49.5 at -115 with ESPN BET.
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Tip 3: Moneyline – Who wins?
Second tip — Moneyline (Who wins): Los Angeles Rams moneyline at BetMGM Sportsbook. L.A. has been the more consistent team, posting an average scoring margin north of +10 per game and holding opponents under 16 per contest. San Francisco has been in more one-score territory on average. The Rams’ road production (27.8 per game) combines with a defense conceding just 15.5 away from home—an efficient profile in a rivalry spot. There’s respect for Shanahan’s script at Levi’s, but the edge tilts to McVay’s side. Tip: Rams ML (BetMGM).
Tip 3: Spread – Los Angeles Rams -3.0
Third tip — Spread: Los Angeles Rams -3.0 at -120 with BetMGM. If you’re laying points, you want trust in defense and drive finishing; the Rams bring both. Their away splits line up with winning margin potential, and their situational late-game execution has been strong during this run. San Francisco is always schematically clever, but with health questions and some variance in late-game defense, L.A. by 4-7 feels like the right landing zone. Tip: Rams -3.0 at -120.
Team news
From the latest notes available: San Francisco’s medical picture has been a weekly storyline. Nick Bosa previously dealt with hip/oblique issues, but per the provided reports, he was not on the most recent list after returning to action. Trent Williams is slated to miss another game with an ankle issue. Guard Ben Bartch (ankles) and rookie safety Malik Mustapha (chest/shoulder) were ruled out. Brock Purdy (toe) has been labeled questionable and at one point was considered available only in an emergency capacity, while Dre Greenlaw (knee) and Isaac Guerendo (foot) were among those tagged as questionable.
For the Rams: Demarcus Robinson (shoulder) and Beaux Limmer (knee) were among several listed as questionable. Tight end Tyler Higbee (knee) and cornerback Cobie Durant (chest) were ruled out, which could open the door for Emmanuel Forbes Jr. to make his Rams debut in the secondary. Keep an eye on inactives 90 minutes before kickoff—this rivalry often swings on key availability in the trenches and at the skill positions.
San Francisco 49ers performance check
Kyle Shanahan’s group remains dangerous, particularly at home, where they’re 2-1 and averaging about 19.0 points for and 17.0 against. Across nine games, the Niners are putting up about 21.6 per and allowing roughly 20.9—competitive, but not quite the overwhelming margin we’ve seen in peak stretches. Over the last five, they’ve gone 3-2, including a 34-24 road win over the New York Giants in their latest outing, a result that showcased improved second-half execution and better red zone efficiency.
Brock Purdy, when in rhythm and protected, has averaged about 252.7 passing yards per game, creating windows for George Kittle, who’s been humming at roughly 72.7 receiving yards per game this season. The Shanahan run game remains scheme-driven and multiple, and if they get a lead, they can grind tempo and control the clock. Defensively, a healthy Nick Bosa changes everything—pressure off the edge is the one variable that can compress L.A.’s deep shot menu and force shorter throws underneath. The key for San Francisco: protect Purdy, sustain drives with balance, and avoid late-game lapses that have led to narrow losses in recent stretches.
How is the current performance of the Los Angeles Rams
Sean McVay’s Rams are 6-2 with a 3-1 mark on the road. L.A. is averaging about 26.1 points per game and allowing around 15.9—a strong split that travels. Away from home, the Rams have actually ticked up to roughly 27.8 points scored while keeping opponents to 15.5, a profile that explains why oddsmakers shade them as short road favorites. Their last outing was a comprehensive 34-10 win over the New Orleans Saints—clean in the red zone and crisp on scripted drives.
Kyren Williams is the heartbeat of the ground game, averaging about 77.9 rushing yards per contest, and his north-south style sets up the play-action shot plays McVay loves. Matthew Stafford continues to manage the offense with veteran poise—efficient on early downs and selective with risk—which has limited turnover opportunities for opponents. Defensively, L.A. rallies to the ball and tackles well in space. If the Rams get a lead, they shift to a patient, clock-chewing pace, forcing offenses to march the long way.
Team Statistics
- – San Francisco overall: about 21.6 points scored per game, 20.9 allowed. Home: roughly 19.0 scored and 17.0 allowed. Last five: 3-2.
- – Los Angeles overall: about 26.1 points scored per game, 15.9 allowed. Road: roughly 27.8 scored and 15.5 allowed. Last five: 4-1.
- – Head-to-head (last five): Rams 3, 49ers 2. These matchups trend competitive and late-swinging.
Keyplayer Statistics/Momentum/External Factors
- – Brock Purdy: averaging about 252.7 passing yards per game in the recent sample—when protected, he can layer throws and leverage Shanahan’s motion-heavy looks.
- – George Kittle: around 72.7 receiving yards per game; matchup-proof when used as the primary read, especially on crossers and seams.
- – Kyren Williams: about 77.9 rushing yards per game; his steady early-down success puts the Rams in second-and-manageable, opening the entire playbook.
- – Pass rush: Nick Bosa’s presence off the edge is the swing piece for San Francisco. If he affects Stafford’s timing, San Francisco’s coverage can tighten underneath.
- – Health watch: Trent Williams’ ankle absence (per latest notes) strains the 49ers’ protection angles and outside zone timing. For L.A., the absence of Tyler Higbee removes a safety valve, but McVay typically redistributes targets effectively.
- – External factors: 4:25 ET kickoff at Levi’s Stadium, natural grass, typically moderate Bay Area fall conditions. Coaching a chess match is real—McVay’s scripted offense versus Shanahan’s counters and adjustments. Hidden edge could come via special teams field position and late-game time management.
Last direct match: San Francisco 49ers vs Los Angeles Rams
The most recent meeting ended 26-23 for the 49ers in overtime after the game sat 10-7 at the end of regulation, and it came on the road for San Francisco. That one was tight all the way—defensive stands, field position swings, and a fourth-quarter rally that forced extra time. The takeaway for this week: even when the totals look modest early, these two can unlock points late, especially once both play-callers have seen the other’s adjustments.
Performance last 5 matches
- – San Francisco 49ers: 3 wins, 2 losses. The arc has been steady, with a recent uptick in offensive efficiency and opportunistic defense when they get a lead.
- – Los Angeles Rams: 4 wins, 1 loss. L.A. has leaned on balance, a strong road identity, and a defense that limits explosive plays.
Last match results San Francisco 49ers and the Los Angeles Rams
- – San Francisco: 34-24 away win over the New York Giants. A confident road performance that featured effective mid-game adjustments and finishing drives.
- – Los Angeles: 34-10 home win over the New Orleans Saints. The Rams dominated situational football—third downs, red zone, and turnover avoidance—and slammed the door in the second half.
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TrustnBet Final Thoughts
We like three angles. First, Over 49.5 at -115: both offenses can stretch the field, and late-game urgency in a division clash often adds points. Second, Rams moneyline: the road profile (27.8 scored, 15.5 allowed) plus a double-digit average margin points to L.A. securing the win. Third, Rams -3 at -120: if the Rams get to script with a lead, their balance and tackling travel well enough to clear the number. That’s our card—Over, Rams ML, Rams -3—rooted in per-game efficiency, road/home splits, and the current health picture.
