NFL Predictions & Odds – Divisional Round
January football hits different. With the stakes up and the margins thin, this Divisional Round matchups brings a little of everything. Bills at Broncos should be a fascinating altitude chess match, while 49ers-Seahawks renews a hard-nosed rivalry in the Northwest. Sunday gives us Texans-Patriots in a contrasting-styles tilt and Rams-Bears with cold-weather wrinkles. We’re breaking down each matchup with a quick preview, highlighting W-L trends (overall and home/away), and closing with one best bet per game—moneyline, spread, or total—with probabilities and odds. As always, prices move fast, so shop the number and act early.
| Game | Prediction | Date | Bet NOW |
|---|---|---|---|
| Buffalo Bills @ Denver Broncos | Bills ML -110 (52%) | 01/17/2026 |  |
| San Francisco 49ers @ Seattle Seahawks | Under 45.0 -125 (56%) | 01/17/2026 |  |
| Houston Texans @ New England Patriots | Patriots -3 -115 (53%) | 01/18/2026 |  |
| Los Angeles Rams @ Chicago Bears | Under 49.5 -110 (52%) | 01/18/2026 | |
Check out even more Betting Predictions here.
Buffalo Bills @ Denver Broncos
Buffalo’s overall W-L profile has traveled well, while Denver’s home/away splits have swung with game script. The Bills’ offense tends to sustain drives better than Denver’s, and their road situational defense has held up in key moments. With both sides looking near a coin flip on paper, QB play is the separator. Betting tip: Bills moneyline -110 (implied 52%). The edge under center and late-down efficiency nudges Buffalo in a tight one.
San Francisco 49ers @ Seattle Seahawks
This rivalry often tightens up, regardless of the records. Seattle’s home W-L has typically been strong, but San Francisco’s overall W-L and road form keep this within one-score rhythms. Defensive fronts on both sides can stall drives, and red-zone efficiency could regress toward field goals. Betting tip: Under 45.0 points -125 (implied 56%). In a divisional grinder with familiar tendencies, the under has the better angle.
Houston Texans @ New England Patriots
Houston’s overall W-L has spiked with explosive plays, but New England’s home W-L and defensive structure can flatten big-play variance. The Patriots’ home situational numbers (third-down and red zone) often tick up in Foxborough, and Houston’s road W-L can wobble when forced into long drives. Betting tip: Patriots -3 (-115, implied 53%). Trust the home defense and field position to cover a short number.
Los Angeles Rams @ Chicago Bears
The Rams’ overall W-L leans on passing efficiency, while Chicago’s home W-L sees improvement with a controlled pace and defense. In colder conditions, both sides may lean run and quick-game, shortening possessions. That generally compresses totals and raises the importance of special teams and turnovers. Betting tip: Under 49.5 points -110 (implied 52%). Pace, weather profile, and red-zone volatility point to a modest scoring script.
