NFL Predictions & Odds Week 18
Week 18 is always a vibes check: win-and-in stakes for some, seeding fine-tuning for others, and a few rivalry games with pure bragging rights. Headliners? Ravens-Steelers under the lights feels like old-school AFC North football. Chiefs-Raiders is never quiet in Vegas. Packers-Vikings and Seahawks-49ers add serious divisional spice. Jets-Bills could swing postseason positioning, and Cowboys-Giants rarely disappoint, no matter the records. Below, we’ve got concise previews and one betting pick per game with probability estimates and American odds only. We rotate markets—moneyline, totals, spreads—so you get a best-angle read for every matchup. Buckle up: here are our betting predictions for every game on the card.
Do you want to read more betting Tips? Just head over to our Betting Predictions section.

Carolina Panthers @ Tampa Bay Buccaneers
Tampa’s overall form and home split have trended better than Carolina’s road profile. The Bucs have protected Raymond James more consistently, while the Panthers’ away results have lagged. Tip: Bucs moneyline -164 (Bet365), ~62% win chance. Tampa’s steadier defense and situational offense at home make the ML the safer play.
Seattle Seahawks @ San Francisco 49ers
San Francisco’s home body of work has outpaced Seattle’s away splits, with the Niners typically controlling the trenches at Levi’s. Seattle’s offense travels in spurts, but the pace and explosives can pop. Tip: Over 44.5 (-116), ~54% chance to go over. Both offenses have enough efficiency to push this past the mid-40s.
New Orleans Saints @ Atlanta Falcons
Atlanta’s home résumé has looked steadier than New Orleans’ road performances. The Falcons’ defense has been tougher at home, and the offense finds rhythm indoors. Tip: Falcons -4.5 (-116), ~54% cover chance. With the dome advantage and slightly better home/road split, Atlanta by a touchdown is in range.
Cleveland Browns @ Cincinnati Bengals
Cincy’s overall win-loss profile at home has been stronger than Cleveland’s typical road form. The Bengals tend to start fast at Paycor, and that matters in a rivalry tilt. Tip: Bengals moneyline -333 (BetMGM), ~77% win chance. Pricey, but the home edge and QB play make the ML a solid anchor.
Indianapolis Colts @ Houston Texans
Houston’s home results and passing efficiency have given them an edge, while Indy’s road form has been streaky. Tip: Over 40.0 (-115), ~53% chance to go over. With both offenses capable of chunk plays and late scoring, this total sits low enough to clear.
Tennessee Titans @ Jacksonville Jaguars
Jacksonville’s home split has offered more reliability than Tennessee’s road output. The Jags’ pass rush and perimeter speed tilt this. Tip: Jaguars -10.5 (-105), ~51% cover chance. The number’s big, but Jacksonville’s explosive-play margin at home can separate late.
Green Bay Packers @ Minnesota Vikings
Minnesota’s home form in tight games has been slightly more trustworthy than Green Bay’s road swings. Expect a tactical, lower-variance approach at U.S. Bank. Tip: Vikings moneyline +105 (DraftKings), ~49% win chance. Even coin-flippy, we’ll take plus money on the home side.
Dallas Cowboys @ New York Giants
Rivalry game with variance: Dallas’ offense can explode, while the Giants’ home efforts have spiked at times. Tip: Over 52.5 (-105), ~51% chance to go over. With both pass games able to generate explosives and late-game scoring potential, this can climb into the high 50s.
New York Jets @ Buffalo Bills
Buffalo’s home profile is notably stronger than the Jets’ road results. The Bills’ offense tends to surge at Highmark; Jets must keep pace. Tip: Bills -9.5 (-111), ~53% cover chance. If Buffalo starts fast, the Jets’ offense may struggle to answer in a two-score game.
Detroit Lions @ Chicago Bears
Cold-weather tilt favors the more balanced home side. Chicago’s home split has improved, while Detroit’s road defense can wobble. Tip: Bears moneyline +105 (DraftKings), ~49% win chance. In a near coin flip, give us the home dog in a physical game.
Los Angeles Chargers @ Denver Broncos
Denver’s defense at altitude plus an improving offense has elevated the Broncos’ home results; L.A.’s road form has been volatile. Tip: Over 42.5 (-111), ~53% chance to go over. Short fields and late-game scoring can push this past the low 40s.

Arizona Cardinals @ Los Angeles Rams
The Rams’ home split and red-zone efficiency outpace Arizona’s road profile. McVay’s offense usually scripts early success at SoFi. Tip: Rams -4.5 (-111), ~53% cover chance. L.A.’s passing game should create margin by the fourth quarter.
Kansas City Chiefs @ Las Vegas Raiders
The Chiefs’ overall form and road steadiness have been better than Vegas’ home volatility. Tip: Chiefs moneyline -250 (DraftKings), ~71% win chance. Mahomes typically handles AFC West trips; the ML is a sturdy parlay piece or moneyline play.
Miami Dolphins @ New England Patriots
New England’s home defense has tightened, while Miami’s road results can ebb. Tempo may be measured. Tip: Under 46.5 (-110), ~52% chance to stay under. Weather and pace point to a mid-40s ceiling.
Baltimore Ravens @ Pittsburgh Steelers
Classic AFC North slugfest. Pittsburgh’s home split thrives on defense and field position, while Baltimore travels well but faces a hostile spot. Tip: Steelers +3.5 (-120), ~55% chance to cover. In a tight, low-margin rivalry, the hook is valuable.