NFL Week 15 Predictions & Odds
NFL Week 15 is here, and with playoff races tightening, every snap carries extra weight. This week delivers several marquee matchups that could reshape the postseason picture, including the Buffalo Bills @ New England Patriots, a clash of two explosive offenses; Baltimore Ravens @ Cincinnati Bengals, where Baltimore’s physicality meets Bangal’s potential; and Minnesota Vikings @ Dallas Cowboys. With so much on the line, fans can expect intensity, urgency, and plenty of standout performances.
As always, we provide betting predictions for every game on the slate, breaking down matchups using detailed analysis, team trends, injury updates, and situational edges. Our picks aren’t guesses—they’re based on data-driven reasoning and real football context. Whether it’s identifying mismatches, evaluating momentum, or spotting value in the lines, we explain exactly why we choose each side. Get ready for a high-stakes week and informed betting insights from kickoff to final whistle.
| Game | Prediction | Date | Bet NOW! |
|---|---|---|---|
| Atlanta Falcons @ Tampa Bay Buccaneers | Bucs ML -227 | 12/11/2025 |  |
| Cleveland Browns @ Chicago Bears | Browns +8 (-118) | 12/14/2025 |  |
| Baltimore Ravens @ Cincinnati Bengals | Under 52.5 (-110) | 12/14/2025 | |
| Arizona Cardinals @ Houston Texans | Texans ML -143 | 12/14/2025 |  |
| New York Jets @ Jacksonville Jaguars | Jaguars -11.5 (-110) | 12/14/2025 | |
| Los Angeles Chargers @ Kansas City Chiefs | Under 42.5 (-105) | 12/14/2025 |  |
| Buffalo Bills @ New England Patriots | Bills ML -110 | 12/14/2025 | |
| Washington Commanders @ New York Giants | Giants -1.5 (-115) | 12/14/2025 | |
| Las Vegas Raiders @ Philadelphia Eagles | Under 39.5 (-110) | 12/14/2025 | |
| Green Bay Packers @ Denver Broncos | Packers ML +102 | 12/14/2025 | |
| Detroit Lions @ Los Angeles Rams | Lions +6 (-125) | 12/14/2025 | |
| Carolina Panthers @ New Orleans Saints | Under 41.0 (-125) | 12/14/2025 | |
| Indianapolis Colts @ Seattle Seahawks | Seahawks ML -185 | 12/14/2025 | |
| Tennessee Titans @ San Francisco 49ers | 49ers -11.5 (-125) | 12/14/2025 | |
| Minnesota Vikings @ Dallas Cowboys | Under 48.5 (-125) | 12/14/2025 | |
| Miami Dolphins @ Pittsburgh Steelers | Steelers ML -164 | 12/15/2025 | |
Find even more tips on our NFL predictions page.
Atlanta Falcons @ Tampa Bay Buccaneers
Tampa’s overall form and home ledger look steadier than Atlanta’s road results. The Bucs’ defense at Raymond James has generally traveled well across game scripts. Win-loss trends tilt Tampa here. Prediction: Moneyline — Buccaneers -227. Win probability: Buccaneers 69%.
Cleveland Browns @ Chicago Bears
Chicago’s overall W-L pace and home mark at Soldier Field outpoint Cleveland’s road profile. Even with the Bears favored, this number gives the Browns breathing room against a sometimes conservative Chicago offense.
Prediction: Spread — Browns +8 (-118). Win probability: Bears 77%.
Baltimore Ravens @ Cincinnati Bengals
Baltimore’s overall record trend edges Cincinnati, and the Ravens’ road form has been reliable. With both defenses capable of tightening in big moments, points could come at a premium.
Prediction: Totals — Under 52.5 (-110). Win probability: Ravens 58%.
Arizona Cardinals @ Houston Texans
Houston’s overall W-L and home split look stronger than Arizona’s road résumé. The Texans’ balanced approach should control tempo and field position at NRG.
Prediction: Moneyline — Texans -143. Win probability: Texans 59%.
New York Jets @ Jacksonville Jaguars
Jacksonville’s overall W-L and home body of work give them a real edge; the Jets’ road results have been uneven. If the Jags jump early, game script favors a cover.
Prediction: Spread — Jaguars -11.5 (-110). Win probability: Jaguars 69%.
Los Angeles Chargers @ Kansas City Chiefs
The Chiefs’ overall W-L and Arrowhead split remain upper-tier, while the Chargers’ road form has been up and down. Expect KC’s defense to compress this into a lower-scoring divisional fight.
Prediction: Totals — Under 42.5 (-105). Win probability: Chiefs 68%.
Buffalo Bills @ New England Patriots
Buffalo’s overall W-L and road split stack up better than New England’s home form. Even in Foxborough, the Bills’ late-season offense usually travels.
Prediction: Moneyline — Bills -110. Win probability: Bills 52%.
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Washington Commanders @ New York Giants
Overall form is tight, but the Giants’ home performance has been inconsistent while Washington’s road ledger is middling. Still, matchups favor a chippy, close game—and the number is short.
Prediction: Spread — Giants -1.5 (-115). Win probability: Giants 36% (upset angle).
Las Vegas Raiders @ Philadelphia Eagles
Philly’s overall and home W-L splits are among the league’s best; the Raiders’ road split has struggled. If the Eagles control pace, this profiles as a methodical, lower total. Prediction: Totals — Under 39.5 (-110). Win probability: Eagles 85%.
Green Bay Packers @ Denver Broncos
Overall records are close; Denver’s altitude helps its home split, but Green Bay’s road form has been competitive. With two volatile offenses, slight value on the better QB play late.
Prediction: Moneyline — Packers +102. Win probability: Packers 50%.
Detroit Lions @ Los Angeles Rams
The Rams’ overall and home W-L stand up; Detroit’s road split is scrappy enough to hang. If this turns into a field-position game, getting a full six matters.
Prediction: Spread — Lions +6 (-125). Win probability: Rams 50%.
Carolina Panthers @ New Orleans Saints
Carolina’s overall form trends better and the road split has held up; New Orleans’ home results have been uneven. Defenses should keep this compressed.
Prediction: Totals — Under 41.0 (-125). Win probability: Panthers 56%.
Indianapolis Colts @ Seattle Seahawks
Seattle’s overall W-L and dominant home split at Lumen Field are strong indicators; the Colts’ road W-L is spotty. Noise and pass rush should tilt it.
Prediction: Moneyline — Seahawks -185. Win probability: Seahawks 65%.
Tennessee Titans @ San Francisco 49ers
San Francisco’s overall and home W-L are elite; Tennessee’s road split hasn’t traveled. If the Niners get the ground game rolling, the gap can widen.
Prediction: Spread — 49ers -11.5 (-125). Win probability: 49ers 79%.
Minnesota Vikings @ Dallas Cowboys
Dallas’ overall and home W-L trends look stronger than Minnesota’s road profile. In a matchup of explosive spikes, a few stalled drives should matter.
Prediction: Totals — Under 48.5 (-125). Win probability: Cowboys 45%.
Miami Dolphins @ Pittsburgh Steelers
Pittsburgh’s overall and home W-L are sturdy; Miami’s road form has fluctuated in tougher environments. Expect the Steelers to lean defense and situational football.
Prediction: Moneyline — Steelers -164. Win probability: Steelers 62%.
