NFL Week 16 Predictions & Odds
It’s late-December football, which means playoff math, cold-weather edges, and some nasty trenches. Week 16 kicks off at the cacophony that is Lumen Field as the Rams visit the Seahawks on Thursday night. Sunday’s slate is loaded: Chiefs-Titans brings contrasting styles, Bengals-Dolphins screams shootout potential, while Packers-Bears renews a rivalry that never gets old. Lions host the Steelers in a physical late-window spot, and Texans-Raiders has big AFC seeding implications. Prime time features Patriots at Ravens on SNF and the 49ers traveling to Indy on MNF. Below, we’ve got concise previews and one betting tip per game—some moneyline, totals, and spread—plus probability estimates and up-to-date odds to help you make smart, responsible plays. Good luck out there. Check out more tips on our NFL Picks page.
| Game | Prediction | Date | Bet NOW |
|---|---|---|---|
| Rams @ Seahawks | Seahawks ML +105 | 12/18/2025 |  |
| Eagles @ Commanders | Under 45.0 -110 | 12/20/2025 |  |
| Packers @ Bears | Bears +2.5 -110 | 12/20/2025 | |
| Buccaneers @ Panthers | Buccaneers ML -154 | 12/21/2025 | |
| Bills @ Browns | Under 42.5 -110 | 12/21/2025 |  |
| Chargers @ Cowboys | Chargers +2.0 -110 | 12/21/2025 | |
| Jets @ Saints | Jets ML +180 | 12/21/2025 | |
| Vikings @ Giants | Under 44.5 -110 | 12/21/2025 | |
| Chiefs @ Titans | Chiefs -3.0 -115 | 12/21/2025 | |
| Bengals @ Dolphins | Bengals ML -115 | 12/21/2025 | |
| Falcons @ Cardinals | Under 48.5 -125 | 12/21/2025 | |
| Jaguars @ Broncos | Broncos -2.5 -120 | 12/21/2025 | |
| Steelers @ Lions | Lions ML -263 | 12/21/2025 |  |
| Raiders @ Texans | Under 38.5 -125 | 12/21/2025 | |
| Patriots @ Ravens | Ravens -2.5 -115 | 12/21/2025 | |
| 49ers @ Colts | 49ers ML -150 | 12/22/2025 | |
Los Angeles Rams @ Seattle Seahawks
Short week, loud house. Seattle’s home-field noise tilts third downs, while the Rams’ protection has had shaky patches away from L.A. Market implies a tight one. Betting tip (Moneyline): Seahawks ML at +105 (DraftKings). Estimated 49% win chance as a live home dog.
Philadelphia Eagles @ Washington Commanders
Division tilt where familiarity keeps things chippy. Philly’s road offense travels, but Washington’s defense can muddy red-zone trips. Betting tip (Totals): Under 45.0 at -110 (best price) with a 54% hit probability in a grindy script.
Green Bay Packers @ Chicago Bears
Rivalry at Soldier Field, likely a trench-heavy December game. Chicago’s defense has improved at home; Green Bay’s offense can stall on long fields. Betting tip (Spread): Bears +2.5 at -110 (best price). About 53% chance to cover in a one-score slugfest.
Tampa Bay Buccaneers @ Carolina Panthers
Tampa’s defensive front should create negative plays; Panthers need a clean turnover sheet to hang. Betting tip (Moneyline): Buccaneers ML at -154 (BetMGM). We estimate a 61% win chance on the road.
Buffalo Bills @ Cleveland Browns
Lakefront December football usually means conservative calls. Buffalo can play from ahead; Cleveland’s defense keeps totals in check at home. Betting tip (Totals): Under 42.5 at -110. Estimated 55% probability given pace and field-position dynamics.
Los Angeles Chargers @ Dallas Cowboys
Indoor track in Arlington favors speed, but Chargers’ pass game can keep Dallas honest. Betting tip (Spread): Chargers +2.0 at -110. Roughly 52% cover probability with backdoor potential in a high-leverage fourth quarter.
Here is more about Dallas Cowboys betting options.
New York Jets @ New Orleans Saints
Superdome edges the Saints, but the Jets’ defense can compress explosives and flip field position. Betting tip (Moneyline): Jets ML at +180 (Bet365). We peg a 36% upset chance—worthy of a sprinkle at this price.
Minnesota Vikings @ New York Giants
Two offenses that can get bogged down by pressure and situational penalties. MetLife winds can matter in December. Betting tip (Totals): Under 44.5 at -110. Estimated 54% chance to cash with field goals over touchdowns.
Kansas City Chiefs @ Tennessee Titans
Tennessee wants to shorten possessions; Kansas City’s early-script offense can flip game state fast. Betting tip (Spread): Chiefs -3.0 at -115. About 54% cover likelihood if KC plays from ahead and forces the Titans into pace.
Cincinnati Bengals @ Miami Dolphins
Speed on speed. If Cincinnati protects, they can sustain drives and keep Miami’s offense cold. Betting tip (Moneyline): Bengals ML at -115 (Bet365). We estimate a 53% win chance in a near coin flip.
Atlanta Falcons @ Arizona Cardinals
Both teams can lean run and shorten games, particularly in the red zone. Betting tip (Totals): Under 48.5 at -125. About 56% probability if drives stall into field goals.
Jacksonville Jaguars @ Denver Broncos
Mile High December often compresses totals and favors Denver’s defense. Jaguars’ offense has been streaky in tough environments. Betting tip (Spread): Broncos -2.5 at -120 (BetMGM). Estimated 55% cover chance with altitude edge.
Pittsburgh Steelers @ Detroit Lions
Detroit’s offense in the dome is tough; Steelers must win on defense and hidden yards. Betting tip (Moneyline): Lions ML at -263 (DraftKings). We project a 72% win chance at Ford Field.
Las Vegas Raiders @ Houston Texans
Houston’s defense drives the game state; Raiders must avoid long down-and-distance. Betting tip (Totals): Under 38.5 at -125. Estimated 57% to the Under in a defense-first script.
New England Patriots @ Baltimore Ravens
Ravens’ ground game plus home-field at night is a tough combo. Pats need turnovers to flip this. Betting tip (Spread): Ravens -2.5 at -115 (Bet365). About 56% cover probability if Baltimore controls tempo.
San Francisco 49ers @ Indianapolis Colts
Indy can be feisty at home, but San Francisco’s trench play and YAC threats travel. Betting tip (Moneyline): 49ers ML at -150 (DraftKings). We estimate a 60% win chance on MNF.
