Seattle Seahawks @ Arizona Cardinals 09/25/2025
Thursday night lights in the desert rarely disappoint, and Week 4’s NFC West clash checks all the boxes for an early-season tone-setter. The Seattle Seahawks head down to Glendale to face the Arizona Cardinals at State Farm Stadium on Thursday, 09/25/2025, with kickoff slated for 8:15. The Seahawks are riding high after a commanding 44-13 home win over the New Orleans Saints in Week 3, highlighted by Kenneth Walker III’s two rushing touchdowns, Jaxon Smith-Njigba’s first touchdown of the season, and rookie Tory Horton’s franchise-record 95-yard punt return touchdown. Seattle, however, has some key injury concerns, with cornerback Devon Witherspoon, safeties Julian Love and Nick Emmanwori, and running back Zach Charbonnet all listed as doubtful.
Arizona, meanwhile, is off to a crisp 2-0 start under Jonathan Gannon and 1-0 at home, allowing just 17.5 points per game while scoring 23.5. The Cardinals are managing their own setbacks, including cornerback Garrett Williams on injured reserve, while Max Melton and safety Will Johnson are day-to-day. Despite a close 15-16 road loss to San Francisco, Arizona has shown it can grind, tackle, and keep games tight against top-tier competition.
Historically, this series has leaned Seattle: the Seahawks have won five straight head-to-head meetings, including the last one in Glendale by 30-18. Early-season form says defense and discipline; history says Seattle has the answers. The lines say buckle up — margins should be razor thin in a game that could set the tone for the NFC West.
Make game day more exciting with our easy-to-follow NFL betting odds and guide!
Our betting predictions for the match Seattle Seahawks @ Arizona Cardinals
Tip 1: Spread — Seattle Seahawks +2.5
Our betting tip: Spread — Seattle Seahawks +2.5 at -110 with ESPN BET Sportsbook. In a matchup with minimal separation, give me the points with a team that’s been consistently sharp against this opponent. Seattle’s defense under Mike Macdonald looks synced early and is allowing just 17.0 per game. With the Seahawks already 1-0 on the road and winners of five straight versus Arizona, +2.5 gives them multiple paths to cash — outright win or a one-score game that lands inside the number.
Discover exclusive insights and top offers inside our expert ESPN BET Sportsbook review.
Tip 2: Moneyline — Seattle Seahawks to Win
Our second betting prediction: Moneyline — Seattle Seahawks to win at best odds (FanDuel Sportsbook). The market has both sides near even for good reason, but constant pressure and smart situational football have leaned Seattle in this rivalry. Arizona’s 23.5 per-game scoring is legit, yet Seattle’s defense has held up against contrasting styles, and their offense flashed ceiling last week. In a one-possession script, I’m siding with the team that’s owned this matchup and has a polished road profile.
Tip 3: Total — Under 43.5 points
Our prediction: Total — Under 43.5 points at -110 with FanDuel. The numbers point to a controlled, field-position battle: Arizona’s allowing 17.5 per game, Seattle’s allowing 17.0, and both staffs are comfortable leaning into defense on a short week. With both offenses still mixing and matching personnel, red-zone execution could lag, leading to more field goals than touchdowns. This has the feel of a 20-something to high-teens finish that stays under the 43.5.
Team news
It’s a short-week turnaround, which almost always favors organized defenses and tested special teams units. Arizona returns home after a physical road trip to San Francisco; Jonathan Gannon’s staff has emphasized tackling and coverage leverage, and it’s showing up in the early-season results. On the Seattle side, Mike Macdonald’s structure — rotating fronts and disguises — has brought quick dividends. Monitor final injury reports for both teams as Thursday approaches, especially at cornerback and on the offensive lines; protection and perimeter matchups will be critical in what profiles as a field-position game. Travel isn’t intimidating for Seattle here — they’ve already won once away — and tempo should be measured with both teams comfortable huddling and controlling the clock when they have a lead.
Arizona Cardinals performance check
Jonathan Gannon’s Cardinals have found a groove early: 2-0 overall with a 1-0 home mark and a point profile that fits their identity. They’ve averaged 23.5 points per game while allowing just 17.5, a clean balance built on early-down efficiency and an opportunistic defense. Their most recent outing — a 15-16 road loss to the 49ers — showcased how they want games to unfold: close, physical, and decided by a handful of third downs and late stops. Arizona’s tackling angles and pursuit have been excellent, a big reason they’ve limited explosive gains.
On offense, Arizona’s approach blends rhythm throws with a steady run complement to stay ahead of the sticks. Without diving into individual yardage totals, it’s evident the Cardinals are emphasizing ball security and manageable third downs rather than chasing explosives. At home, that’s often a winning formula. Special teams have complemented the defense by controlling hidden yardage, and the coverage units have done their job. In the NFC West context, Arizona’s 2-0 start puts them shoulder to shoulder with the division’s heavy hitters, and this prime-time spot is exactly the kind of checkpoint that can confirm staying power.
How is the current performance of the Seattle Seahawks
In Year 2 of the roster reboot and Year 2 of the new direction, Mike Macdonald’s Seattle defense looks like the headline act. The Seahawks are allowing just 17.0 points per game across two, and they’ve already banked a road win. Coming off a 44-13 home win over the Saints, their offense showed it can press the gas when game script permits. But the calling card remains situational defense: tighter red-zone execution and timely pressure have kept opponents in check, creating shorter fields and calmer fourth quarters.
Offensively, Seattle stays balanced and doesn’t need to chase chunk plays to function. Protection and run-game sequencing set up makeable throws, and Seattle’s skill group is capable of winning isolated matchups without forcing the issue. Again, we’re not listing raw yardage here, but the consistency is there. With ballhawking tendencies on defense and clean operation on offense, Seattle has been a good road traveler — methodical, composed, and comfortable winning in the 20s. In a division where margins are thin, their track record against Arizona carries weight, and their current form suggests they can hold serve in a possession-by-possession contest.
Statistics
- – Last direct match Arizona Cardinals vs. Seattle Seahawks: 30-18, away win for Seattle — a result that underscores Seattle’s ability to execute on the road in this rivalry.
- – Head-to-head last 5 meetings (all competitions): Arizona 0 wins, Seattle 5 wins.
- – Performance last 5 matches (all competitions): Arizona 3 wins, 2 losses; Seattle 3 wins, 2 losses.
- – Last match results: Arizona lost 15-16 away to San Francisco; Seattle won 44-13 at home against New Orleans.
- – Season scoring profiles (averages): Arizona 23.5 points for, 17.5 against; Seattle 22.0 points for, 17.0 against. – Home/away form: Arizona is 1-0 at home; Seattle is 1-0 away.
Context matters: The averages point to a controlled pace and a premium on red-zone conversion. Arizona’s home comfort typically tightens its coverage and reduces mistakes, while Seattle’s defensive structure travels. That’s a strong underpinning for the Under and a compelling reason to take points with Seattle in a basically even matchup.
TrustnBet Final Thoughts
This is a prototypical Thursday nighter with both teams geared to play clean, efficient football. We’re leaning into three pillars. First, Spread: Seattle +2.5 — the points matter in a rivalry that’s been one-score friendly, and Seattle’s profile on the road is trustworthy. Second, Moneyline: Seattle — the five-game head-to-head run and defensive consistency give the Seahawks the late-game edge. Third, Total: Under 43.5— both defenses have started fast, and on a short week, execution tends to favor a lower total. Put it together, and the path to cashing centers on Seattle’s composure and a game script that stays inside the 40s.
| Curious for more Betting Predictions? | |
|---|---|
| 🏟️ Expert betting predictions all Sports | 🚀 Parlay bet picks |
| 🏈 NFL expert picks | 🏀 NBA expert picks |
| 🏒 NHL picks | ⚽ Soccer expert picks |
| 🏁 Nascar predictions | 🎾 Tennis expert predictions |
| 🥊 UFC predictions |
