Tennessee Titans @ Denver Broncos 09/07/2025
A new NFL season, a fresh sheet of paper, and a late-afternoon kickoff at altitude: the Titans head to Empower Field at Mile High to face the Broncos on Sunday at 4:05 p.m. ET. In a spot that often amplifies home-field edge, Denver enters with preseason momentum and two clear betting storylines: a steady trend in their form and a Tennessee team still searching for traction in meaningful games. The Broncos’ last outing was a 28-19 road win over the Saints, while their final NFL game of 2024 ended in a 7-31 road loss to Buffalo. Average those most recent two appearances and you get a baseline snapshot: Denver at 17.5 points scored and 25.0 allowed, a wide split that should tighten with the roster set and the playbook trimmed for Week 1 under Sean Payton.
Denver’s defense has been dominant throughout the preseason, ranking No. 1 in scoring, total, pass, and third-down defense while allowing the fewest first downs. With a deep front and an elite secondary, this unit could be among the league’s best if it stays healthy.
On the other side, Tennessee closed its tune-up window with a 23-13 home win over the Vikings but finished last NFL season with a 14-23 home loss to Houston. Across those two latest showings, the Titans sit at 18.5 points per game scored and 18.0 allowed—quietly balanced, but the bigger context matters: they’re 0-5 in their last five NFL games and 2-3 across the last five in all competitions. The Titans have also rebuilt their offensive line, adding Dan Moore Jr. at tackle, shifting JC Latham to the right side, and signing veteran Kevin Zeitler. With first-rounders Latham and Peter Skoronski plus free-agent pickups Moore and center Lloyd Cushenberry III, Tennessee’s front now looks deeper and more capable of protecting the quarterback and establishing the run.
Denver’s more recent surge in all competitions (4-1), combined with the thin air and opener energy, makes the moneyline and spread markets particularly attractive for the home side. Add in a manageable totals line, and you’ve got a clean three-leg setup for bettors who prefer clarity over chaos in Week 1.
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Our betting predictions for the match Tennessee Titans @ Denver Broncos
Main Tip: Spread – Denver Broncos -8.0
First tip — Spread: Our betting prediction is Denver Broncos -8.0 at -110 with Fanatics. Week 1 numbers can be volatile, but Denver’s combination of home altitude, recent all-competitions confidence, and Sean Payton’s scripting edge gives the Broncos a path to win by a margin. Tennessee has taken five straight NFL losses, and while Brian Callahan’s offense will evolve, asking a new staff to go punch-for-punch at Mile High right away is a tall order. The pick: Broncos -8.0 at -110 at Fanatics Sportsbook.
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Tip 2: Denver on the moneyline
Second tip — Moneyline: Our betting tip is Denver on the moneyline at FanDuel Sportsbook at very competitive odds. It’s a rich price for a reason: Denver’s situational advantages, paired with Tennessee’s recent NFL skid, tilt this toward a solid home result. If you don’t love laying points in Week 1, the moneyline is the steadier way to back the better setup and coaching continuity at home. The pick: Broncos moneyline.
Tip 3: Game total – Over 41.5 Points
Third tip — Game total: Our prediction is Over 41.5 at -110 with FanDuel. Even with both teams averaging in the high teens across their last two listed games, the opener environment and scripted drives lend themselves to early scoring. Denver should create short fields off defensive pressure and special teams, while Tennessee’s offense under Callahan can generate enough chunk plays to nudge this past the mid-40s. The pick: Over 41.5 at -110 with FanDuel.
Team news
It’s the first official game week, so volatility is naturally lower than the preseason churn—depth charts are largely settled, and conditioning is front and center. Denver leans into a strong home opener narrative with coaching continuity under Sean Payton. Tennessee brings a fresh identity under Brian Callahan, a modern offensive mind who’ll lean into timing, spread concepts, and high-percentage reads. Monitor practice participation for late-week clarifications, but both teams appear set to roll out their core groups.
Denver Broncos performance check
Under Sean Payton, Denver’s preseason finish looked crisp, culminating in that 28-19 win at New Orleans. Paired with the last NFL game of 2024 (a 7-31 road loss in Buffalo), their two-game snapshot averages out to 17.5 points scored and 25.0 allowed. The Broncos are 4-1 in their last five in all competitions and 2-3 in their last five NFL contests when spanning the end of last season. This is a Week 1 reset, and the design points to a cleaner offensive operation—quicker decisions, a measured run-pass balance, and scripted tempo early to take control. Altitude is a real factor; Denver’s front seven often plays faster at home out of the gate, and that can flip field position quickly.
Division context matters: the Broncos are in the AFC West with Kansas City, the Chargers, and the Raiders. Every home game is precious currency in a division race that’s often tight behind the Chiefs. Denver can’t afford to drop opener equity, and that urgency, paired with Payton’s play sequencing, should make third-down execution a focal point. Expect Denver to emphasize efficient first-down gains to avoid long-yardage stress and to attack Tennessee’s second level with quick hitters that function like extensions of the run game. If Denver’s protection holds, they can turn drives into productive red-zone trips—another reason the spread is playable.
How is the current performance of Tennessee Titans
Brian Callahan’s arrival signals a transition to a more modern, QB-friendly structure. The Titans’ recent all-competitions ledger (2-3) shows flashes, including the 23-13 win over Minnesota, but when you isolate NFL results, they’ve dropped five straight. Across their two latest listed games (Vikings win and Texans loss), they average 18.5 points scored and 18.0 allowed. That defensive figure hints at resilience, but the real test is sustaining drives at altitude and finishing possessions with touchdowns, not field goals.
In division terms, Tennessee is in the AFC South with Houston, Jacksonville, and Indianapolis. It’s a winnable division if the offense matures quickly and the defense can limit explosives. Here, though, the situational challenges stack up: first game of the year, on the road, against a defense that can lean on crowd noise and an offense expected to be sharper in Payton’s second year. Tennessee’s path covers controlling tempo—leaning on a steady run rate early, deploying quick-game concepts to neutralize pass rush, and leveraging play-action to generate mid-level throws. If they stay on schedule, they can keep this within a score into the fourth. But the median outcome still favors Denver by margin, which aligns with both the spread and moneyline angles.
Statistics
– Last direct match: Tennessee Titans 17-10 Denver Broncos (home win for the Titans). – Head-to-Head (last 5, all competitions): Titans 3 wins, Broncos 2 wins. – Performance last five matches (all competitions): Denver 4 wins, 1 loss; Tennessee 2 wins, 3 losses. – Last match results: Denver won 28-19 on the road against the Saints; Tennessee won 23-13 at home versus the Vikings. – Last NFL match of previous season: Denver lost 7-31 at Buffalo; Tennessee lost 14-23 at home to Houston.
Contextualizing scoring via averages from the most recent two listed games:
- Broncos: 17.5 points per game scored, 25.0 allowed.
- Titans: 18.5 points per game scored, 18.0 allowed.
Those averages don’t define ceiling—especially in a Week 1 environment—but they frame expectations: Denver projects to improve their scoring efficiency at home, and Tennessee’s defense, while competitive, may face short-field stress if special teams and turnovers tilt to the Broncos.
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TrustnBet Final Thoughts
Put it together—form, coaching, location—and the board lines up cleanly. We’re comfortable backing Denver multiple ways. First, the spread at -8.0 lines up with a home opener edge and Tennessee’s recent NFL skid. Second, the moneyline at FanDuel Sportsbook is the safer entry for bettors who want to minimize variance while endorsing the better matchup and coaching continuity. Third, over 41.5 fits a script where Denver’s offense capitalizes on early scripting and Tennessee generates enough in the second half to push the pace. We’re not overreacting to preseason box scores; we’re reading the situation—Payton’s planning, altitude, and a Titans team still building its identity under Callahan. That mix gives Denver every chance to control this one and push it over the mid-40s.
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