Musetti vs Djokovic Odds: Australian Open Picks & Where to Watch Live
On paper, this quarterfinal feels like a classic contrast in styles and career arcs, the kind that makes bettors sit up and take notice. Lorenzo Musetti, the 23‑year‑old Italian who’s finally started to justify the hype on hard courts, carved his way to the final eight by dismantling Taylor Fritz in straight sets — a result that is itself a statement about how much his all‑court game has matured this season.
Across the net will stand Novak Djokovic, a 38‑year‑old chasing Slam history, who hasn’t been tested at this event since his fourth‑round opponent withdrew with an injury. Djokovic already etched another milestone at this tournament, recording his 400th Grand Slam match win and matching Roger Federer’s record for Australian Open victories along the way
In a vacuum, this is “experience vs. rising star”; in betting, it’s “proven precision vs. creative volatility.” Let’s dig into what the hard numbers say. Start betting with the best price plus the latest bet365 bonus code!

Musetti vs Djokovic Odds Outlook & Expert Picks
Match Winner Odds (best @ bet365)

Pick: Novak Djokovic Moneyline
Djokovic isn’t just playing well — he’s cruising through this tournament with authority and rest on his side. There’s a reason his odds sit at -275 on bet365: his game translates to pressure tennis, and Musetti’s best attacks are neutralized by Djokovic’s return depth and decision‑making under duress. The Serb’s Slam experience, particularly at the Australian Open, where he’s been champion ten times, means he’s likely to dominate long rallies and tilt tight games in his favor.
Set Betting Odds (best @ bet365)

Pick 2: Djokovic 3–1 Set Score
If you’re chasing a bit more value but don’t want to leap into a shock outcome, look at Djokovic 3–1. This price (+260 at bet365) reflects a scenario I think is very realistic: Musetti, fired up by his best Slam draw yet, snatches a set on a good run — perhaps eking out early break momentum or catching Djokovic flat in a set — but eventually succumbs to the Serb’s adjustments.
The beauty of this play is that it respects Musetti’s talent and recent form while still backing the reality that Djokovic has the tools and experience to reel him back in and close the match in four.
Game Totals Odds (best @ bet365)

Pick 3: Over 39.5 Total Games
When two contrasting players meet — one creative and the other relentless — longer rallies and momentum swings tend to happen. Musetti’s improved hard‑court consistency means he’s more likely to extend sets and avoid getting blown off the court. If he takes a set, that alone bumps the game total significantly. Even in a four‑set match, the odds -110 at bet365 of the over hitting here are strong because Musetti’s variety forces Djokovic into patterns that elevate both players’ game counts.
Special Pick: Musetti to Win at Least One Set
If you want a protective hedge or a ticket booster, backing Musetti to take a set is a smart angle. The Italian has shown he can dictate points when he’s firing forehand winners and serving big — and we’ve seen him take a set off Djokovic before in a hard‑court final last season.
This is not a prediction that Musetti will win the match — it’s a realistic nod to his capacity to carve out momentum and pressure points, which often translates to at least one set on a big stage.
If you’re building your tennis betting card today, our Tennis Betting Guide & Odds Center breaks down moneylines, set betting, totals, and the best sportsbook prices in one place.

What The Stats Say: Head-to-Head & Career Snapshot
Surface Breakdown (last 10 H2Hs)
| Surface | Djokovic | Musetti |
|---|---|---|
| Hard | 2 | 0 |
| Clay | 4 | 1 |
| Indoor | 2 | 0 |
| Grass | 1 | 0 |
Expert Take: Djokovic dominates across all surfaces, with Musetti’s only win coming on clay. On hard courts, Djokovic’s depth, consistency, and return game make him extremely difficult to challenge.
Career Comparison: Experience vs Potential
| Category | Djokovic | Musetti |
|---|---|---|
| Current Ranking | 4th | 5th |
| ATP Titles | 101+ | 2 |
| Grand Slams | 24 | 0 |
| Masters Titles | 40+ | 0 |
| Main Tour Wins | 1100+ | 180+ |
| H2H Meetings (10) | 9 | 1 |
| Recent Form | W W W W W W | W W W W L W |
Expert Take: Djokovic’s unmatched experience, Grand Slam record, and consistent recent form favor him heavily. Musetti is talented but inconsistent in pressure matches and has fewer titles to rely on in high-stakes situations.
Final Betting Card
| Bet Type | Pick | Odds (bet365) |
|---|---|---|
| Moneyline | Djokovic | -275 |
| Set Betting (Best Value) | Djokovic 3–1 | +260 |
| Total Games | Over 39.5 | -110 |
| Set Betting | Musetti to Win at Least One Set | -120 |
Where to Watch (U.S.)
- Live Streaming: ESPN+ (via app or web)
- Television: ESPN & ESPN2
- Replays: ESPN+

Final Prediction: Lorenzo Musetti vs Novak Djokovic
Novak Djokovic def. Lorenzo Musetti 6–3, 4–6, 6–3, 6–2
Musetti will have flashes of brilliance and might steal a set if he’s striking clean, but Djokovic’s depth, consistency, and elite tactical control make him extremely hard to stop. He will gradually neutralize Musetti’s angles, control the baseline, and close out a professional, low-drama victory — a dependable outcome for bettors while still offering value on totals and set props.
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